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Zuplenz Dosage

Generic name: ondansetron (oral)
Brand names: Zofran, Zofran ODT, Zuplenz
Drug class: 5HT3 receptor antagonists

Medically reviewed by  A Ras MD.


 Recommended Adult Dosing

Dosage forms:  STRIP: 4 mg, 8 mg

Nausea/vomiting prevention, chemo-related

[highly-emetogenic chemo]
Dose: 24 mg PO x1 30min before chemo; Info: use for single-day chemo regimens
[moderately-emetogenic chemo]
Dose: 8 mg PO q8h x2 doses, then 8 mg PO q12h until 1-2 days after chemo complete; Start: 30min before chemo

Nausea/vomiting prevention, postop

[16 mg PO x1]
Info: give 1h before anesthesia

Nausea/vomiting prevention, XRT-related

[total body XRT]
Dose: 8 mg PO x1, give 1-2h before each fraction of XRT
[single high-dose fraction abdominal XRT]
Dose: 8 mg PO q8h until 1-2 days after XRT complete; Start: 1-2h before XRT
[daily fractionated abdominal XRT]
Dose: 8 mg PO q8h; Start: 1-2h before each fraction of XRT

Nausea/vomiting, gastroenteritis-related

[8 mg PO q8h prn]

Renal dosing

[no adjustment]
renal impairment: no adjustment
HD/PD: no adjustment; no supplement

Hepatic dosing

[adjust dose amount]
Child-Pugh Class C: max 8 mg/24h



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