Zuplenz Dosage

Generic name: ondansetron (oral)
Brand names: Zofran, Zofran ODT, Zuplenz
Drug class: 5HT3 receptor antagonists

Medically reviewed by A Ras MD.

Recommended Adult Dosing

Dosage forms: STRIP: 4 mg, 8 mg

[highly-emetogenic chemo]

Dose: 24 mg PO x1 30min before chemo; Info: use for single-day chemo regimens

[moderately-emetogenic chemo]

Dose: 8 mg PO q8h x2 doses, then 8 mg PO q12h until 1-2 days after chemo complete; Start: 30min before chemo

[16 mg PO x1]

Info: give 1h before anesthesia

[total body XRT]

Dose: 8 mg PO x1, give 1-2h before each fraction of XRT

[single high-dose fraction abdominal XRT]

Dose: 8 mg PO q8h until 1-2 days after XRT complete; Start: 1-2h before XRT

[daily fractionated abdominal XRT]

Dose: 8 mg PO q8h; Start: 1-2h before each fraction of XRT

[8 mg PO q8h prn]

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

[adjust dose amount]

Child-Pugh Class C: max 8 mg/24h

SRC: NLM .