Zosyn Dosage

Generic name: piperacillin and tazobactam

Drug class: Beta-lactamase inhibitors

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  INJ

Intra-abdominal infections

[3.375 g IV q6h x4-7 days]
Info: for appendicitis or peritonitis

Gynecologic infections

[3.375 g IV q6h x7-10 days]
Info: for postpartum endometritis or PID

Skin/skin structure infections

[3.375 g IV q6h x7-10 days]

Pneumonia

[hospital-acquired or ventilator-assoc.]
Dose: 4.5 g IV q6h x7 days; Info: may extend duration based on clinical response; refer to IDSA guidelines
[community-acquired]
Dose: 4.5 g IV q6h x7 days; Info: for inpatient tx; refer to IDSA guidelines

*Febrile neutropenia, chemo-induced

[4.5 g IV q6h]
Info: for empiric tx in high-risk pts

Renal dosing

[if usual dose 3.375 g q6h]
CrCl 20-40: 2.25 g q6h; CrCl <20: 2.25 g q8h
HD: 2.25 g q12h; give 0.75 g as supplement after dialysis if next maint. dose not due right after dialysis; PD: 2.25 g q12h; no supplement
[if usual dose 4.5 g q6h]
CrCl 20-40: 3.375 g q6h; CrCl <20: 2.25 g q6h
HD: 2.25 g q8h; give 0.75 g as supplement after dialysis if next maint. dose not due right after dialysis; PD: 2.25 g q8h; no supplement

Hepatic dosing

[no adjustment]

SRC: NLM .