Zosyn Dosage

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ

Intra-abdominal infections

[3.375 g IV q6h x4-7 days]

Info: for appendicitis or peritonitis

Gynecologic infections

[3.375 g IV q6h x7-10 days]

Info: for postpartum endometritis or PID

Skin/skin structure infections

[3.375 g IV q6h x7-10 days]

Pneumonia

[hospital-acquired or ventilator-assoc.]

Dose: 4.5 g IV q6h x7 days; Info: may extend duration based on clinical response; refer to IDSA guidelines

[community-acquired]

Dose: 4.5 g IV q6h x7 days; Info: for inpatient tx; refer to IDSA guidelines

*Febrile neutropenia, chemo-induced

[4.5 g IV q6h]

Info: for empiric tx in high-risk pts

Renal dosing

[if usual dose 3.375 g q6h]

CrCl 20-40: 2.25 g q6h; CrCl <20: 2.25 g q8h

HD: 2.25 g q12h; give 0.75 g as supplement after dialysis if next maint. dose not due right after dialysis; PD: 2.25 g q12h; no supplement

[if usual dose 4.5 g q6h]

CrCl 20-40: 3.375 g q6h; CrCl <20: 2.25 g q6h

HD: 2.25 g q8h; give 0.75 g as supplement after dialysis if next maint. dose not due right after dialysis; PD: 2.25 g q8h; no supplement

Hepatic dosing

[no adjustment]

SRC: NLM .