Zortress Dosage

Dosage forms:  TAB: 0.25 mg, 0.5 mg, 0.75 mg, 1 mg

Kidney transplant rejection prophylaxis

[0.75 mg PO q12h]

Start: ASAP post-transplant; Info: for pts w/ low-mod immunologic risk; part of multi-drug regimen; may adjust dose q4-5 days based on trough levels; if trough level <3 ng/mL double total daily dose; if 2 consecutive trough level >8 ng/mL decr. dose by 0.5 mg/day; give consistently w/ food or on empty stomach; do not cut/crush/chew tab

Liver transplant rejection prophylaxis

[1 mg PO q12h]

Start: >30 days post-transplant; Info: part of multi-drug regimen; may adjust dose q4-5 days based on trough levels; if trough level <3 ng/mL double total daily dose; if 2 consecutive trough level >8 ng/mL decr. dose by 0.5 mg/day; give consistently w/ food or on empty stomach; do not cut/crush/chew tab

Renal dosing

renal impairment: no adjustment

HD/PD: not defined

Hepatic dosing

[adjust dose amount]

Child-Pugh Class A: decr. start dose 33%; Child-Pugh Class B or C: decr. start dose 50%