Zoloft Dosage

Generic name: sertraline
Drug class: Selective serotonin reuptake inhibitors

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 25 mg, 50 mg, 100 mg; SOL: 20 mg per mL

Major depressive disorder

[50-200 mg PO qd]

Start: 50 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C

Obsessive-compulsive disorder

[50-200 mg PO qd]

Start: 50 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C

Panic disorder

[50-200 mg PO qd]

Start: 25 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C

Post-traumatic stress disorder

[50-200 mg PO qd]

Start: 25 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C

Premenstrual dysphoric disorder

[daily dosing]

Dose: 50-150 mg PO qd; Start: 50 mg PO qd, may incr. by 50 mg/day w/ each menstrual cycle; Max: 150 mg/day; Info: taper dose gradually to D/C

[luteal phase dosing]

Dose: 50-100 mg PO qd during luteal phase; Start: 50 mg PO qd during luteal phase; Max: 100 mg/day; Info: if inadequate response w/ 50 mg PO qd, may give 50 mg PO qd x3 days, then incr. to 100 mg PO qd w/ each luteal phase dosing cycle

Social anxiety disorder

[50-200 mg PO qd]

Start: 25 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

[adjust dose amount]

Child-Pugh Class A: decr. dose 50%; Child-Pugh Class B or C: avoid use

SRC: NLM .