Zokinvy Dosage

Generic name: lonafarnib
Drug class: Miscellaneous metabolic agents

Medically reviewed by A Ras MD.

Recommended Adult Dosing

Dosage forms: CAP: 50 mg, 75 mg

Hutchinson-Gilford progeria syndrome

[150 mg/m^2/dose PO bid]

Start: 115 mg/m^2/dose PO bid x4mo, then incr. to 150 mg/m^2/dose PO bid as tolerated; Info: round dose to nearest 25 mg increment; give w/ meals

Processing-deficient progeroid laminopathy

[150 mg/m^2/dose PO bid]

Start: 115 mg/m^2/dose PO bid x4mo, then incr. to 150 mg/m^2/dose PO bid as tolerated; Info: for pts w/ heterozygous LMNA mutation w/ progerin-like protein accumulation, or for pts w/ homozygous or compound heterozygous ZMPSTE24 mutation; round dose to nearest 25 mg increment; give w/ meals

Renal dosing

[not defined]

HD/PD: not defined

Hepatic dosing