Zocor Dosage

Generic name: simvastatin
Drug class: Statins

Medically reviewed by  A Ras MD. Last updated Oct 6, 2022

 Recommended Adult Dosing

Dosage forms:  TAB: 10 mg, 20 mg, 40 mg, 80 mg

Special Note

[restricted 80 mg dose]
Info: max simvastatin dose 40 mg/day; as of 6/8/2011, any pt previously on 80 mg/day w/o muscle toxicity x12mo may remain on this dose; do not incr. dose to 80 mg/day in any other pts; switch to alternative tx if LDL-C goal not met on 40 mg/day

Primary hyperlipidemia

[20-40 mg PO qpm]
Max: 40 mg/day; Info: may adjust dose starting 4wk after tx initiation

Heterozygous familial hypercholesterolemia

[20-40 mg PO qpm]
Max: 40 mg/day; Info: may adjust dose starting 4wk after tx initiation

Homozygous familial hypercholesterolemia, adjunct tx

[20-40 mg PO qpm]
Max: 40 mg/day; Info: may adjust dose starting 4wk after tx initiation

Hypertriglyceridemia

[20-40 mg PO qpm]
Max: 40 mg/day; Info: may adjust dose starting 4wk after tx initiation

Primary dysbetalipoproteinemia

[20-40 mg PO qpm]
Max: 40 mg/day; Info: may adjust dose starting 4wk after tx initiation

Cardiovascular event risk reduction

[20-40 mg PO qpm]
Info: may adjust dose starting 4wk after tx initiation; refer to ACC/AHA cholesterol guideline

Atherosclerotic cardiovascular dz

[20-40 mg PO qpm]
Info: may adjust dose starting 4wk after tx initiation; refer to ACC/AHA cholesterol guideline

Renal dosing

[adjust dose amount]
CrCl 15-29: start 5 mg qpm; CrCl <15: not defined
HD/PD: not defined

Hepatic dosing

acute hepatic failure or decompensated cirrhosis: contraindicated

 

SRC: NLM .