Zerbaxa Dosage

Generic name: ceftolozane and tazobactam
Drug class: Cephalosporins / beta-lactamase inhibitors

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ

Special Note

[strength clarification]

Info: doses expressed as total ceftolozane + tazobactam amt; 1.5 g ceftolozane/tazobactam contains 1 g ceftolozane + 0.5 g tazobactam

Intra-abdominal infections, complicated

[1.5 g IV q8h x4-14 days]

Info: give w/ metronidazole 500 mg PO/IV q8h; duration varies by infection site/severity

UTI, complicated

[1.5 g IV q8h x7 days]

Pneumonia, hospital-acquired or ventilator-assoc.

[3 g IV 8h x7 days]

Info: may extend duration based on clinical response; refer to IDSA guidelines

Renal dosing

[complicated UTI or intra-abdominal infections]

CrCl 30-50: 750 mg q8h; CrCl 15-29: 375 mg q8h; CrCl <15: not defined; ESRD: 750 mg x1, then 150 mg q8h

HD: 750 mg x1, then 150 mg q8h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined

[pneumonia, hospital-acquired or ventilator-assoc.]

CrCl 30-50: 1.5 g q8h; CrCl 15-29: 750 mg q8h; CrCl <15: not defined; ESRD: 2.25 g x1, then 450 mg q8h

HD: 2.25 g x1, then 450 mg q8h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined

Hepatic dosing

[no adjustment]

SRC: NLM .