Zepatier Dosage

Generic name: elbasvir and grazoprevir
Drug class: Antiviral combinations

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 50 mg/100 mg

Hepatitis C infection, chronic

[genotype 1]
Dose: 1 tab PO qd x12wk or x16wk; Info: screen for NS5A polymorphism in pts w/ genotype 1a; duration depends on genotype subtype, prior tx; may give w/ ribavirin if tx-experienced; refer to AASLD/IDSA hepatitis C guidelines
[*genotype 3]
Dose: 1 tab PO qd w/ sofosbuvir x12wk; Info: for tx-experienced pts w/ compensated cirrhosis; refer to AASLD/IDSA hepatitis C guidelines
[genotype 4]
Dose: 1 tab PO qd x12wk; Info: duration depends on prior tx; refer to AASLD/IDSA hepatitis C guidelines

Renal dosing

renal impairment: no adjustment
HD: no adjustment; no supplement; PD: not defined

Hepatic dosing

Child-Pugh Class B or C: contraindicated

 

 

SRC: NLM .