Zepatier Dosage
Generic name: elbasvir and grazoprevir
Drug class: Antiviral combinations
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 50 mg/100 mg
Hepatitis C infection, chronic
- [genotype 1]
- Dose: 1 tab PO qd x12wk or x16wk; Info: screen for NS5A polymorphism in pts w/ genotype 1a; duration depends on genotype subtype, prior tx; may give w/ ribavirin if tx-experienced; refer to AASLD/IDSA hepatitis C guidelines
- [*genotype 3]
- Dose: 1 tab PO qd w/ sofosbuvir x12wk; Info: for tx-experienced pts w/ compensated cirrhosis; refer to AASLD/IDSA hepatitis C guidelines
- [genotype 4]
- Dose: 1 tab PO qd x12wk; Info: duration depends on prior tx; refer to AASLD/IDSA hepatitis C guidelines
Renal dosing
- renal impairment: no adjustment
- HD: no adjustment; no supplement; PD: not defined
Hepatic dosing
- Child-Pugh Class B or C: contraindicated
SRC: NLM .