Zenpep Dosage

Generic name: pancrelipase
Drug class: Digestive enzymes

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  DR CAP (lipase/protease/amylase): 3K units/10K units/14K units, 5K units/17K units/24K units, 10K units/32K units/42K units, 15K units/47K units/63K units, 20K units/63K units/84K units, 25K units/79K units/105K units, 40K units/126K units/168K units

Special Note

[formulation clarification]

Info: pancrelipase products not interchangeable; do not switch between products

Exocrine pancreatic insufficiency

[500-2500 lipase units/kg/dose PO w/ each meal/snack]

Start: 500 lipase units/kg/dose PO w/ each meal/snack; Alt: 500-4000 lipase units/g fat ingested/day PO divided w/ meals/snacks; Info: snack dose usually half of meal dose; may open caps and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; doses >2500 lipase units/kg/meal, 4000 lipase units/g fat ingested/day, or 10,000 lipase units/kg/day require objective evidence of improved efficacy

Renal dosing

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

Hepatic dosing

[not defined]

 Recommended Peds Dosing

Dosage forms:  DR CAP (lipase/protease/amylase): 3K units/10K units/14K units, 5K units/17K units/24K units, 10K units/32K units/42K units, 15K units/47K units/63K units, 20K units/63K units/84K units, 25K units/79K units/105K units, 40K units/126K units/168K units

Special Note

[formulation clarification]

Info: pancrelipase products not interchangeable; do not switch between products

Exocrine pancreatic insufficiency

[<1 yo]

Dose: 3000 lipase units PO per breastfeeding or 4 oz formula; Info: may open caps and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; give before breastfeeding or formula

[1-3 yo]

Dose: 1000-2500 lipase units/kg/dose PO w/ each meal/snack; Start: 1000 lipase units/kg/dose PO w/ each meal/snack; Max: 6000 lipase units/kg/meal; Alt: 500-4000 lipase units/g fat ingested/day PO divided w/ meals/snacks; Info: snack dose usually half of meal dose; may open caps and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; doses >2500 lipase units/kg/meal, 4000 lipase units/g fat ingested/day, or 10,000 lipase units/kg/day require objective evidence of improved efficacy

[4-11 yo]

Dose: 500-2500 lipase units/kg/dose PO w/ each meal/snack; Start: 500 lipase units/kg/dose PO w/ each meal/snack; Max: 6000 lipase units/kg/meal; Alt: 500-4000 lipase units/g fat ingested/day PO divided w/ meals/snacks; Info: snack dose usually half of meal dose; may open caps and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; doses >2500 lipase units/kg/meal, 4000 lipase units/g fat ingested/day, or 10,000 lipase units/kg/day require objective evidence of improved efficacy

[12 yo and older]

Dose: 500-2500 lipase units/kg/dose PO w/ each meal/snack; Start: 500 lipase units/kg/dose PO w/ each meal/snack; Alt: 500-4000 lipase units/g fat ingested/day PO divided w/ meals/snacks; Info: snack dose usually half of meal dose; may open caps and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; doses >2500 lipase units/kg/meal, 4000 lipase units/g fat ingested/day, or 10,000 lipase units/kg/day require objective evidence of improved efficacy

Renal dosing

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

Hepatic dosing

[not defined]

SRC: NLM .