Zelboraf Dosage

Generic name: vemurafenib
Drug class: Multikinase inhibitors

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Special Note

[uses, dosing may vary]
Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

Melanoma, unresectable or metastatic

[monotherapy]
Dose: 960 mg PO q12h; Info: for pts w/ BRAF V600E mutation
[*combo w/ cobimetinib]
Dose: 960 mg PO q12h; Info: for pts w/ BRAF V600E or V600K mutation
[*combo w/ atezolizumab and cobimetinib]
Dose: 960 mg PO q12h on days 1-21, then 720 mg PO q12h on days 22-28 of 28-day cycle for cycle 1, then starting cycle 2, give 720 mg PO q12h on days 1-28 of 28-day cycle; Info: for pts w/ BRAF V600 mutation

Erdheim-Chester dz (ECD)

[960 mg PO q12h]
Info: for pts w/ BRAF V600 mutation

Renal dosing

CrCl >30: no adjustment; CrCl <30: not defined
HD/PD: not defined

Hepatic dosing

bilirubin 1-3x ULN: no adjustment; bilirubin >3x ULN: not defined

 

SRC: NLM .