Zegerid Dosage

Generic name: omeprazole and sodium bicarbonate
Drug class: Proton pump inhibitors

Medically reviewed by  A Ras MD. Last updated Oct 6, 2022

 Recommended Adult Dosing

Dosage forms:  CAP: 20 mg/1100 mg, 40 mg/1100 mg; PWDR: 20 mg/1680 mg per pkt, 40 mg/1680 mg per pkt

Special Note

[dosing clarification]

Info: two 20 mg cap not bioequivalent to one 40 mg cap, two 20 mg pkt not bioequivalent to one 40 mg pkt due to sodium bicarbonate component; doses based on omeprazole component

GERD

[non-erosive, symptomatic]

Dose: 20 mg PO/NG qd x4-8wk; Info: give >1h before meals; do not open cap, see PPI Administration Alternatives table

[erosive esophagitis, short-term tx]

Dose: 20 mg PO/NG qd x4-12wk; Info: give >1h before meals; do not open cap, see PPI Administration Alternatives table

[erosive esophagitis, maintenance tx]

Dose: 20 mg PO/NG qd; Info: give >1h before meals; do not open cap, see PPI Administration Alternatives table

Duodenal ulcer

[20-40 mg PO/NG qd x4-8wk]

Info: usual maint. dose 20 mg qd; give >1h before meals; do not open cap, see PPI Administration Alternatives table

Gastric ulcer

[40 mg PO/NG qd x4-8wk]

Info: give >1h before meals; do not open cap, see PPI Administration Alternatives table

Upper GI bleeding prophylaxis, critically ill pts

[40 mg NG/OG qd x14 days]

Start: 40 mg NG/OG x1, then 40 mg NG/OG x1 6-8h later; Info: suspend tube feeding 3h before and 1h after; do not use cap; see PPI Administration Alternatives table

Gastric ulcer prophylaxis, NSAID-assoc.

[20-40 mg PO/NG qd]

Info: give >1h before meals; do not open cap, see PPI Administration Alternatives table

Hypersecretory conditions

[individualize dose PO/NG qd-tid]

Start: 60 mg PO/NG qd; Info: doses up to 120 mg PO tid have been used; divide doses >80 mg/day; give >1h before meals; do not open cap, see PPI Administration Alternatives table

Renal dosing

renal impairment: no adjustment; Info: caution advised, sodium bicarbonate may cause sodium retention

HD/PD: not defined

Hepatic dosing

[erosive esophagitis, maintenance tx]

hepatic impairment: avoid use

[all other indications]

hepatic impairment: not defined

SRC: NLM .