Zarxio Dosage

Generic name: filgrastim-sndz
Drug class: Colony stimulating factors

Medically reviewed by  A Ras MD. Last updated Oct 6, 2022

 Recommended Adult Dosing

Dosage forms:  INJ (pre-filled syringe): 300 mcg per 0.5 mL, 480 mcg per 0.8 mL

Special Note

[formulation clarification]

Info: nonproprietary name = filgrastim-sndz

Febrile neutropenia prophylaxis, chemo-induced

[5 mcg/kg/dose SC/IV qd]

Start: >24h after chemo, may incr. dose by 5 mcg/kg/dose per chemo cycle; Info: for pts w/ non-myeloid malignancies or pts w/ AML receiving induction or consolidation chemo; SC route preferred; product not recommended for direct admin. of doses <180 mcg; cont. until ANC >10,000 or for up to 2wk; do not give w/in 24h before chemo

Neutropenia, post-BMT

[10 mcg/kg/dose IV qd]

Start: >24h after chemo, >24h after BMT; Info: product not recommended for direct admin. of doses <180 mcg; decr. dose by 50% if ANC >1000 x3 consecutive days, then D/C if ANC >1000 x3 more consecutive days; incr. dose back to 10 mcg/kg/day if ANC <1000 during 50% dose reduction; restart 5 mcg/kg/day if ANC <1000 after tx D/C

Peripheral blood progenitor cell mobilization

[10 mcg/kg/dose SC qd]

Start: 4 days before 1st leukapheresis, cont. through last leukapheresis; Info: product not recommended for direct admin. of doses <180 mcg; D/C if WBC >100,000

Neutropenia, severe chronic

[congenital]

Start: 6 mcg/kg/dose SC bid; Info: product not recommended for direct admin. of doses <180 mcg; individualize dose based on ANC and clinical course

[idiopathic or cyclic]

Start: 5 mcg/kg/dose SC qd; Info: product not recommended for direct admin. of doses <180 mcg; individualize dose based on ANC and clinical course

Renal dosing

renal impairment: no adjustment

HD/PD: not defined

Hepatic dosing

[no adjustment]

SRC: NLM .