Zanamivir Dosage

Generic Name: zanamivir

Brand Name: Relenza

Drug Class: , Neuraminidase Inhibitors

Medically reviewed by A Ras MD Last updated Oct 6, 2022

 Recommended Adult Dosing

Dosage forms:  DPI: 5 mg per blister

Special Note

[www.cdc.gov/flu]
Info: >99% of currently circulating influenza virus in US is zanamivir-susceptible
[formulation clarification]
Info: admin. dry powder via Diskhaler only; do not reconstitute in liquid or nebulize

Influenza A and B (seasonal flu) tx, uncomplicated

[2 puffs inhaled q12h x5 days]
Start: w/in 48h of sx onset; Info: give 2 doses on Day 1 as long as >2h between doses; may extend tx if immunocompromised

Influenza A and B (seasonal flu) prophylaxis

[pre-exposure]
Dose: 2 puffs inhaled q24h; Start: when influenza activity detected in community; Info: for pts at very high risk of developing complications who cannot receive influenza vaccine; give for duration of community influenza activity
[post-exposure]
Dose: 2 puffs inhaled q24h x7 days after last known exposure; Start: w/in 48h of exposure
[community outbreak]
Dose: 2 puffs inhaled q24h x28 days; Start: w/in 5 days of identified community outbreak
[institutional setting]
Dose: 2 puffs inhaled q24h for at least 14 days; Start: ASAP after identified outbreak; Info: give x7 days after last known case

Renal dosing

[no adjustment]
renal impairment: no adjustment
HD: no adjustment, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: no adjustment; no supplement

Hepatic dosing

[not defined]

 Recommended Peds Dosing

Dosage forms:  DPI: 5 mg per blister

Special Note

[www.cdc.gov/flu]
Info: >99% of currently circulating influenza virus in US is zanamivir-susceptible
[formulation clarification]
Info: admin. dry powder via Diskhaler only; do not reconstitute in liquid or nebulize

Influenza A and B (seasonal flu) tx, uncomplicated

[7 yo and older]
Dose: 2 puffs inhaled q12h x5 days; Start: w/in 48h of sx onset; Info: give 2 doses on Day 1 as long as >2h between doses; may extend tx if immunocompromised

Influenza A and B (seasonal flu) prophylaxis

[pre-exposure, 5 yo and older]
Dose: 2 puffs inhaled q24h; Start: when influenza activity detected in community; Info: for pts at very high risk of developing complications who cannot receive influenza vaccine; give for duration of community influenza activity
[post-exposure, 5 yo and older]
Dose: 2 puffs inhaled q24h x7 days after last known exposure; Start: w/in 48h of exposure
[community outbreak, adolescents]
Dose: 2 puffs inhaled q24h x28 days; Start: w/in 5 days of identified community outbreak
[institutional setting, 5 yo and older]
Dose: 2 puffs inhaled q24h for at least 14 days; Start: ASAP after identified outbreak; Info: give x7 days after last known case

Renal dosing

renal impairment: no adjustment
HD/PD: not defined, consider adult renal dosing for guidance

Hepatic dosing

[not defined]
SRC: NLM .