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Zanaflex Dosage

Generic name: tizanidine
Drug class: Skeletal muscle relaxants

Medically reviewed by  A Ras MD. Last updated Oct 6, 2022

 Recommended Adult Dosing

Dosage forms:  CAP: 2 mg, 4 mg, 6 mg; TAB: 4 mg

Special Note

[formulation clarification]
Info: cap and tab bioequivalent only if fasting, not bioequivalent if fed; caution advised if switching between formulations


[individualize dose PO q6-8h prn]
Start: 2 mg PO x1, may repeat q6-8h prn; Max: 3 doses/24h up to 36 mg/day; Info: may incr. by 2-4 mg/dose q1-4 days; give consistently w/ food or on empty stomach; taper dose by 2-4 mg/day to D/C if prolonged, high-dose use

Renal dosing

[adjust dose amount]
CrCl <25: decr. usual dose, amount not defined; Info: clearance decr. by >50%
HD/PD: not defined

Hepatic dosing

[adjust dose amount]
hepatic impairment: decr. usual dose, amount not defined



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