Xyntha Dosage

Generic name: antihemophilic factor (recombinant)
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ

Hemophilia A

[bleeding episode, minor]

Dose: individualize dose IV x1; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 20-40%

[bleeding episode, moderate]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%

[bleeding episode, major]

Dose: individualize dose IV q8-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 60-100%

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then q8-24h until healing complete; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 60-100%

[bleeding prophylaxis, routine]

Dose: 30 units/kg/dose IV 3x/wk; Info: adjust dose based on clinical response

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .