Xultophy Dosage

Generic name: insulin degludec and liraglutide

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ (pen): 100 units/3.6 mg per mL

Diabetes mellitus, type 2

[basal insulin or GLP-1 agonist tx-naive pts]

Dose: 10-50 units SC qd; Start: D/C basal insulin or GLP-1 agonist, then start insulin degludec/liraglutide 10 units SC qd, may adjust dose by 2 units/day no more frequently than 1-2x/wk; Max: 50 units/day; Info: retitrate from 10 units SC qd if tx interrupted for >3 days

[conversion from basal insulin or GLP-1 agonist]

Dose: 10-50 units SC qd; Start: D/C basal insulin or GLP-1 agonist, then start insulin degludec/liraglutide 16 units SC qd, may adjust dose by 2 units/day no more frequently than 1-2x/wk; Max: 50 units/day; Info: retitrate from 16 units SC qd if tx interrupted for >3 days

Renal dosing

[see below]

renal impairment: consider decr. usual dose

HD/PD: not defined

Hepatic dosing

[no adjustment]

SRC: NLM .