Xtampza ER Dosage

Generic name: oxycodone
Drug class: Narcotic analgesics

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  ER CAP: 9 mg, 13.5 mg, 18 mg, 27 mg, 36 mg

Pain, severe chronic

[opioid-naive or opioid-nontolerant pts]
Dose: individualize dose PO q12h; Start: 9 mg PO q12h, may incr. total daily dose by 25-50% q1-2 days; Info: use lowest effective dose, shortest effective tx duration; titrate slowly in pts 65 yo and older; >36 mg/dose, >72 mg/day for use in opioid-tolerant pts only; give w/ food; may open cap, but do not crush/chew/dissolve contents; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use
[opioid-tolerant pts]
Dose: individualize dose PO q12h; Start: individualize start dose based on current opioid intake, see pkg insert for conversion; may incr. total daily dose by 25-50% q1-2 days; Max: 288 mg/day; Info: use lowest effective dose, shortest effective tx duration; consider low start dose, titrate slowly in pts 65 yo and older; give w/ food; may open cap, but do not crush/chew/dissolve contents; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use

Renal dosing

[see below]
CrCl <60: titrate slowly; use alternative for doses <9 mg
HD/PD: not defined; Info: dose adjustment to doses <9 mg not possible w/ ER cap

Hepatic dosing

hepatic impairment: decr. start dose 50-66%, titrate slowly; use alternative for doses <9 mg; Info: dose adjustment to doses <9 mg not possible w/ ER cap

 

SRC: NLM .