Xpovio Dosage

Generic name: selinexor
Drug class: Miscellaneous antineoplastics

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 20 mg, 40 mg, 50 mg, 60 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, concomitant meds to mitigate toxicity, and dosing incl. toxicity-related dose adjustments

Multiple myeloma, relapsed or refractory

[combo w/ bortezomib and dexamethasone]

Dose: 100 mg PO x1 on day 1 of 7-day cycle; Info: for pts who have received at least 1 prior tx; do not cut/crush/chew tab

[combo w/ dexamethasone]

Dose: 80 mg PO x1 on days 1, 3 of 7-day cycle; Info: for pts who have received at least 4 prior tx, incl. at least 2 proteasome inhibitors, at least 2 immunomodulatory agents, and an anti-CD38 agent; do not cut/crush/chew tab

Diffuse large B-cell lymphoma, relapsed or refractory

[60 mg PO x1 on days 1, 3 of 7-day cycle]

Info: for pts who have received at least 2 lines of tx; do not cut/crush/chew tab

Renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

Hepatic dosing

mild impairment: no adjustment; mod-severe impairment: not defined

SRC: NLM .