Xgeva Dosage

Generic name: denosumab
Drug class: Miscellaneous bone resorption inhibitors

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ: 120 mg per 1.7 mL

bone metastases, solid tumor-assoc.

[120 mg SC q4wk]
Info: for skeletal-related events prevention; avoid invasive dental procedure; calcium and vitamin D supplementation recommended

multiple myeloma

[120 mg SC q4wk]
Info: for skeletal-related events prevention; avoid invasive dental procedure; calcium and vitamin D supplementation recommended

giant cell tumor of bone

[120 mg SC q4wk]
Start: 120 mg SC qwk x3wk, then starting wk 5, 120 mg SC q4wk; Info: avoid invasive dental procedure; calcium and vitamin D supplementation recommended

Hypercalcemia, malignant

[120 mg SC q4wk]
Start: 120 mg SC qwk x3wk, then starting wk 5, 120 mg SC q4wk; Info: avoid invasive dental procedure

Renal dosing

[no adjustment]
renal impairment: no adjustment
HD/PD: no adjustment; no supplement

Hepatic dosing

[not defined]

 

SRC: NLM .