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Xenazine Dosage

Generic name: tetrabenazine
Drug class: VMAT2 inhibitors

Medically reviewed by  A Ras MD.


 Recommended Adult Dosing

Dosage forms:  TAB: 12.5 mg, 25 mg

Huntington dz

[25-100 mg/day PO divided bid-tid]
Start: 12.5 mg PO qam x1wk, then 12.5 mg PO bid x1wk, then may incr. by 12.5 mg/day qwk; Max: 25 mg/dose up to 100 mg/day; Info: divide dose tid if >37.5 mg/day; consider CYP2D6 genotyping if dose requirement >50 mg/day; max 37.5 mg/dose up to 100 mg/day in extensive CYP2D6 metabolizers; max 25 mg/dose up to 50 mg/day in poor CYP2D6 metabolizers; retitrate if tx interrupted for >5 days

Renal dosing

[not defined]
renal impairment: not defined
HD/PD: not defined

Hepatic dosing

hepatic impairment: contraindicated



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