Xeloda Dosage

Generic name: capecitabine
Drug class: Antimetabolites

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  TAB: 150 mg, 500 mg

Special Note

[uses, dosing may vary]
Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

Stage III colon CA, adjuvant tx

[1250 mg/m^2/dose PO bid on days 1-14 of 21-day cycle]
Info: give x8 cycles; give after meals

Colorectal CA, metastatic

[1250 mg/m^2/dose PO bid on days 1-14 of 21-day cycle]
Info: give after meals

Metastatic breast CA, refractory or relapsed

[monotherapy]
Dose: 1250 mg/m^2/dose PO bid on days 1-14 of 21-day cycle; Info: for paclitaxel- and anthracycline-resistant dz; give after meals
[combo w/ docetaxel]
Dose: 1250 mg/m^2/dose PO bid on days 1-14 of 21-day cycle; Info: for anthracycline-resistant dz; give after meals
[*combo w/ lapatinib]
Dose: 1000 mg/m^2/dose PO bid on days 1-14 of 21-day cycle; Info: for pts w/ HER2-overexpressing dz who have received prior tx, incl. anthracycline, taxane, and trastuzumab; give after meals
[*combo w/ neratinib]
Dose: 750 mg/m^2/dose PO bid on days 1-14 of 21-day cycle; Info: for pts w/ HER2-overexpressing dz who have received 2 or more anti-HER2 based regimens; give after meals

Renal dosing

CrCl 30-50: decr. usual dose by 25%; CrCl <30: contraindicated
HD/PD: not defined

Hepatic dosing

mild-mod impairment: caution advised, monitor closely; severe impairment: not defined

 

SRC: NLM .