Wilate Dosage

Generic name: antihemophilic and von Willebrand factor complex
Brand names: Alphanate, Humate-P, Wilate
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by A Ras MD.

Recommended Adult Dosing

Dosage forms: INJ

Von Willebrand dz

[bleeding episode, minor]

Dose: 20-40 units/kg/dose IV x1, then 20-30 units/kg/dose IV q12-24h; Info: individualize dose to maintain trough VWF:RCo and factor VIII levels >30% for up to 3 days; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, major]

Dose: 40-60 units/kg/dose IV x1, then 20-40 units/kg/dose IV q12-24h; Info: individualize dose to maintain trough VWF:RCo and factor VIII levels >50% for up to 5-7 days; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding prophylaxis, minor surgery]

Dose: 30-60 units/kg/dose IV x1, then 15-30 units/kg/dose or 50% of loading dose IV q12-24h; Start: w/in 3h before surgery; Info: individualize dose to maintain trough VWF:RCo level >30% until wound healing achieved, up to 3 days; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors; see pkg insert for alternative loading dose calculation based on pt in vivo recovery

[bleeding prophylaxis, major surgery]

Dose: 40-60 units/kg/dose IV x1, then 20-40 units/kg/dose or 50% of loading dose IV q12-24h; Start: w/in 3h before surgery; Info: give at least 2 doses w/in 1st 24h after start of surgery; individualize dose to maintain trough VWF:RCo level >50% until wound healing achieved; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors; see pkg insert for alternative loading dose calculation based on pt in vivo recovery

Hemophilia A

[bleeding episode, minor]

Dose: 30-40 units/kg/dose IV q12-24h for at least 1 day and until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 20-40%; 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, moderate]

Dose: 30-40 units/kg/dose IV q12-24h x3-4 days or until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%; 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, major]

Dose: 35-50 units/kg/dose IV q12-24h x3-4 days or until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 60-100%; 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, life-threatening]

Dose: 35-50 units/kg/dose IV q8-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 60-100%; 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[routine bleeding prophylaxis]

Dose: 20-40 units/kg/dose IV q2-3 days

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing