Wakix Dosage

Generic name: pitolisant
Drug class: CNS stimulants

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  TAB: 4.45 mg, 17.8 mg

Narcolepsy

[17.8-35.6 mg PO qam]
Start: 8.9 mg PO qam x1wk, then 17.8 mg PO qam x1wk, then may incr. to 35.6 mg PO qam; Max: 35.6 mg/day; Info: max 17.8 mg/day in poor CYP2D6 metabolizers

Renal dosing

[see below]
eGFR 60-89: not defined, caution advised; eGFR 15-59: start 8.9 mg qd x7 days, then incr. to max 17.8 mg/day; eGFR <15: avoid use
HD/PD: not defined

Hepatic dosing

Child-Pugh Class A: no adjustment; Child-Pugh Class B: start 8.9 mg qd x14 days, then incr. to max 17.8 mg/day; Child-Pugh Class C: contraindicated

 

SRC: NLM .