Vyxeos Dosage

Generic name: cytarabine and daunorubicin (liposomal)
Drug class: Antineoplastic combinations

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: not interchangeable w/ liposomal cytarabine-containing products

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

AML

[induction tx]

Dose: 100 mg/m^2/24h IV infusion on days 1-7 of cycle; Alt: 100 mg/m^2/dose IV q12h on days 1-7 of cycle; 200 mg/m^2/24h IV infusion on days 1-7 of cycle; Info: use w/ anthracycline or part of multi-drug chemo regimen

[*consolidation tx, <60 yo]

Dose: 3000 mg/m^2/dose IV q12h on days 1, 3, 5 of each cycle; Info: give x3-4 cycles

[*consolidation tx, >60 yo]

Dose: 100-200 mg/m^2/24h IV infusion on days 1-7 of each cycle; Alt: 100-200 mg/m^2/24h IV infusion on days 1-5 of each cycle; Info: use as monotherapy or w/ anthracycline; give up to 2 cycles

[*low-dose regimen, combo w/ glasdegib]

Dose: 20 mg SC bid on days 1-10 of 28-days cycle; Info: for pts 75 yo and older, or who are ineligible for intensive induction chemo d/t comorbidities; give for at least 6 cycles

[*low-dose regimen, combo w/ venetoclax]

Dose: 20 mg SC qd on days 1-10 of 28-days cycle; Info: for pts 75 yo and older, or who are ineligible for intensive induction chemo d/t comorbidities; cytoreduction may be required if WBC >25,000 prior to 1st dose

Meningeal leukemia

[30 mg/m^2/dose intrathecally q4 days]

Info: for prevention and tx; cont. until CSF normal, then give x1 additional dose

Renal dosing

[standard or low-dose regimen]

renal impairment: no adjustment

HD/PD: not defined

[high-dose regimen]

CrCl 46-60: decr. usual dose by 40%; CrCl 31-45: decr. usual dose by 50%; CrCl <30: consider alternate tx

HD/PD: not defined

Hepatic dosing

[not defined]

hepatic impairment: caution advised, consider decr. dose

SRC: NLM .