Vonvendi Dosage

Generic name: von Willebrand factor (recombinant)
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ

Von Willebrand dz

[bleeding episode, minor]
Dose: 40-50 units/kg/dose IV x1, then 40-50 units/kg/dose IV q8-24h; Info: give 1st dose w/ factor VIII if FVIII:C level is <40% or unknown; dose, duration varies by site/severity of bleeding, severity of dz
[bleeding episode, major]
Dose: 50-80 units/kg/dose IV x1, then 40-60 units/kg/dose IV q8-24h x2-3 days; Info: give 1st dose w/ factor VIII if FVIII:C level is <40% or unknown; individualize dose to maintain trough VWF:RCo >50%; dose, duration varies by site/severity of bleeding, severity of dz
[bleeding prophylaxis, minor surgery]
Dose: 25-30 units/kg/dose IV x1 preop, then individualize dose IV q12-48h for at least 48h; Start: w/in 1h before surgery; Info: may give one additional preop dose 12-24h before surgery; give 1h preop dose w/ factor VIII if FVIII:C level is <30; maintain trough VWF:RCo and factor VIII levels >30% up to 72h post-surgery; dose, duration varies by site/severity of bleeding, severity of dz; see pkg insert for alternative loading dose calculation based on pt in vivo recovery
[bleeding prophylaxis, major surgery]
Dose: 40-60 units/kg/dose IV x1 preop, then individualize dose IV q12-48h for at least 72h; Start: w/in 1h before surgery; Info: may give one additional preop dose 12-24h before surgery; give 1h preop dose w/ factor VIII if FVIII:C level is <60; maintain trough VWF:RCo and factor VIII levels >50% up to 72h, then >30% after 72h post-surgery; dose, duration varies by site/severity of bleeding, severity of dz; see pkg insert for alternative loading dose calculation based on pt in vivo recovery
[bleeding prophylaxis, emergency surgery]
Dose: 40-60 units/kg/dose IV x1 preop; Start: w/in 1h before surgery; Info: give w/ factor VIII if FVIII:C level is <40-50 for minor surgery or <80-100 for major surgery; dose, duration varies by site/severity of bleeding, severity of dz; see pkg insert for alternative dose calculation based on pt in vivo recovery
[routine bleeding prophylaxis]
Dose: 40-60 units/kg/dose IV 2x/wk; Max: 60 units/kg/dose IV 2x/wk; Info: for pts w/ severe type 3 dz receiving on-demand tx

Renal dosing

[not defined]
renal impairment: not defined
HD/PD: not defined

Hepatic dosing

[not defined]

 

SRC: NLM .