Vitrakvi Dosage
Generic name: larotrectinib
Drug class: Multikinase inhibitors
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: CAP: 25 mg, 100 mg; SOL: 20 mg per mL
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
Neurotrophic receptor tyrosine kinase (NTRK) gene fusion-positive solid tumors, metastatic or unresectable
- [100 mg PO bid]
- Info: for refractory dz; do not open/crush/chew cap
Renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
Hepatic dosing
- Child-Pugh Class A: no adjustment; Child-Pugh Class B or C: decr. start dose 50%
SRC: NLM .