Vibativ Dosage

Generic name: telavancin
Drug class: Glycopeptide antibiotics

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ

Skin/skin structure infections, complicated bacterial

[10 mg/kg/dose IV q24h x7-14 days]
Info: duration varies by infection site/severity

Pneumonia, hospital-acquired or ventilator-assoc.

[10 mg/kg/dose IV q24h x7 days]
Info: may extend duration based on clinical response; refer to IDSA guidelines

Renal dosing

[skin/skin structure infections]
CrCl 30-50: 7.5 mg/kg/dose q24h; CrCl 10-29: 10 mg/kg/dose q48h; CrCl <10: not defined; Info: decr. efficacy in pts w/ CrCl <50
HD: consider 10 mg/kg/dose q48h or 10 mg/kg/dose 3x/wk after dialysis; no supplement; PD: not defined; Info: decr. efficacy in pts w/ CrCl <50
[pneumonia]
CrCl 30-50: 7.5 mg/kg/dose q24h; CrCl 10-29: 10 mg/kg/dose q48h; CrCl <10: not defined; Info: weigh risk/benefit if CrCl <50
HD: consider 10 mg/kg/dose q48h or 10 mg/kg/dose 3x/wk after dialysis; no supplement; PD: not defined; Info: weigh risk/benefit if CrCl <50

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

 

SRC: NLM .