Versacloz Dosage

Generic name: clozapine
Brand names: Clozaril, FazaClo, Versacloz
Drug class: Atypical antipsychotics

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  SUSP: 50 mg per mL

Restricted Distribution in US

Schizophrenia, tx-resistant

[150-300 mg PO bid]
Start: 12.5 mg PO qd-bid, incr. by 25-50 mg/day to target 300-450 mg/day in divided doses by day 14, then may incr. by up to 100 mg/day q3-7 days; Max: 900 mg/day; Info: retitrate from 12.5 mg PO qd-bid if tx interrupted >2 days; consider lower dose in poor CYP2D6 metabolizers; taper dose over 1-2wk to D/C

Suicide prevention, schizophrenia-assoc.

[150-300 mg PO bid]
Start: 12.5 mg PO qd-bid, incr. by 25-50 mg/day to target 300-450 mg/day in divided doses by day 14, then may incr. by up to 100 mg/day q3-7 days; Max: 900 mg/day; Info: retitrate from 12.5 mg PO qd-bid if tx interrupted >2 days; consider lower dose in poor CYP2D6 metabolizers; taper dose over 1-2wk to D/C

Renal dosing

[see below]
renal impairment: not defined; Info: consider decr. usual dose if significant impairment
HD/PD: not defined, caution advised

Hepatic dosing

hepatic impairment: not defined; Info: consider decr. usual dose if significant impairment
SRC: NLM .