Versacloz Dosage
Generic name: clozapine
Brand names: Clozaril, FazaClo, Versacloz
Drug class: Atypical antipsychotics
Recommended Adult Dosing
Dosage forms: SUSP: 50 mg per mL
Restricted Distribution in US
Schizophrenia, tx-resistant
- [150-300 mg PO bid]
- Start: 12.5 mg PO qd-bid, incr. by 25-50 mg/day to target 300-450 mg/day in divided doses by day 14, then may incr. by up to 100 mg/day q3-7 days; Max: 900 mg/day; Info: retitrate from 12.5 mg PO qd-bid if tx interrupted >2 days; consider lower dose in poor CYP2D6 metabolizers; taper dose over 1-2wk to D/C
Suicide prevention, schizophrenia-assoc.
- [150-300 mg PO bid]
- Start: 12.5 mg PO qd-bid, incr. by 25-50 mg/day to target 300-450 mg/day in divided doses by day 14, then may incr. by up to 100 mg/day q3-7 days; Max: 900 mg/day; Info: retitrate from 12.5 mg PO qd-bid if tx interrupted >2 days; consider lower dose in poor CYP2D6 metabolizers; taper dose over 1-2wk to D/C
Renal dosing
- [see below]
- renal impairment: not defined; Info: consider decr. usual dose if significant impairment
- HD/PD: not defined, caution advised
Hepatic dosing
- hepatic impairment: not defined; Info: consider decr. usual dose if significant impairment