Venclexta Dosage

Generic name: venetoclax

Brand names: Venclexta, Venclexta Starting Pack
Drug class: Miscellaneous antineoplastics

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 10 mg, 50 mg, 100 mg; convenience pack

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments

[convenience pack components]

Info: 4-wk starting pack contains 10 mg tab x14 and 50 mg tab x7 and 100 mg tab x21

AML, newly diagnosed

[combo w/ azacitidine or decitabine]

Dose: 100 mg PO qd on day 1, then 200 mg PO qd on day 2, then 400 mg PO qd starting day 3 until dz progression; Info: for pts 75 yo and older, or who are ineligible for intensive induction chemo d/t comorbidities; cytoreduction may be required if WBC >25,000 prior to 1st dose; give w/ food; do not cut/crush/chew tab

[combo w/ low-dose cytarabine]

Dose: 100 mg PO qd on day 1, then 200 mg PO qd on day 2, then 400 mg PO qd on day 3, then 600 mg PO qd starting day 4 until dz progression; Info: for pts 75 yo and older, or who are ineligible for intensive induction chemo d/t comorbidities; cytoreduction may be required if WBC >25,000 prior to 1st dose; give w/ food; do not cut/crush/chew tab

CLL/SLL

[monotherapy]

Dose: 20 mg PO qd on wk 1, then 50 mg PO qd on wk 2, then 100 mg PO qd on wk 3, then 200 mg PO qd on wk 4, then 400 mg PO qd starting wk 5 until dz progression; Info: give w/ food; do not cut/crush/chew tab

[combo w/ obinutuzumab]

Dose: 20 mg PO qd on wk 1, then 50 mg PO qd on wk 2, then 100 mg PO qd on wk 3, then 200 mg PO qd on wk 4, then 400 mg PO qd on wk 5-45; Start: on cycle 1 day 22 of obinutuzumab; Info: give w/ food; do not cut/crush/chew tab

[combo w/ rituximab]

Dose: 20 mg PO qd on wk 1, then 50 mg PO qd on wk 2, then 100 mg PO qd on wk 3, then 200 mg PO qd on wk 4, then 400 mg PO qd on wk 5-109; Info: start rituximab on wk 6 after receiving venetoclax 400 mg/day dose x7 days and cont. venetoclax tx x24mo after initiating rituximab; give w/ food; do not cut/crush/chew tab

Renal dosing

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: decr. dose 50%

SRC: NLM .