Urofollitropin Dosage

Generic name: urofollitropin
Brand names: Bravelle, Metrodin, Fertinex
Drug class: Gonadotropins

Medically reviewed by A Ras MD.

Recommended Adult Dosing

Dosage forms: INJ: 75 units per mL

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing

Ovulation induction

[step-up regimen]

Dose: individualize dose SC/IM qd; Start: 37.5-75 units SC/IM qd x14 days, then may incr. by 37.5 units/day no more frequently than qwk; Max: 225 units/day; Info: use lowest effective dose

[step-down regimen]

Dose: 150 units SC/IM qd until dominant follicle development, then decr. to 112.5 units/day x3 days, then decr. to 75 units/day

Assisted reproductive technology

[w/ no menotropins]

Dose: individualize dose SC qd; Start: 225 units SC qd x5 days, then may adjust by up to 75-150 units/day no more frequently than q2 days; Max: 225 units/day for start dose, 450 units/day for subsequent doses; Info: use lowest effective dose

[w/ menotropins]

Dose: individualize dose SC qd; Start: 75 units or 150 units SC qd x5 days, then may adjust dose by up to 75-150 units/day no more frequently than q2 days; Max: 225 units/day for total urofollitropin and menotropins start dose, 450 units/day for total combined subsequent doses; Info: use lowest effective dose

Spermatogenesis induction

[individualize dose SC 3x/wk]

Start: 150 units SC 3x/wk; Max: 300 units 3x/wk; Info: use lowest effective dose; use w/ hCG

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing