Unasyn Dosage

Generic name: ampicillin and sulbactam
Drug class: Beta-lactamase inhibitors

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  INJ

Special Note

[strength clarification]
Info: doses expressed as total ampicillin + sulbactam amt; 1.5 g ampicillin/sulbactam contains 1 g ampicillin + 0.5 g sulbactam

Intra-abdominal infections

[1.5-3 g IM/IV q6h]
Max: 12 g/day; Info: dose, duration varies w/ severity

Skin/skin structure infections, bacterial

[1.5-3 g IM/IV q6h]
Max: 12 g/day; Info: dose, duration varies w/ severity

Infections, bacterial

[1.5-3 g IM/IV q6h]
Max: 12 g/day; Info: dose, duration varies w/ infection type, severity

PID, severe

[3 g IV q6h x14 days]
Info: give w/ doxycycline; not 1st-line agent; switch to PO regimen ASAP to complete course

Sinusitis, severe acute

[1.5-3 g IV q6h x7-10 days]

Infection prophylaxis, surgical

[3 g IV x1]
Start: 60min preop; Info: may repeat dose in 2h

Pneumonia, community-acquired

[1.5-3 g IV q6h for at least 5 days]
Info: for inpatient tx; may be part of multi-drug regimen; refer to IDSA guidelines

Renal dosing

[adjust dose frequency]
CrCl 15-30: give usual dose q12h; CrCl 5-14: give usual dose q24h; CrCl <5: not defined
HD: give usual dose q12-24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: give usual dose q12h; no supplement

Hepatic dosing

ampicillin/sulbactam-assoc. hepatic impairment hx: contraindicated

SRC: NLM .