Tracleer Dosage

Generic name: bosentan
Drug class: Agents for pulmonary hypertension

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 62.5 mg, 125 mg

Restricted Distribution in US

Pulmonary arterial HTN

[<40 kg]

Dose: 62.5 mg PO bid; Max: 125 mg/day; Info: D/C and monitor at least q2wk if AST/ALT >3x up to 8x ULN; may resume prior dose if AST/ALT return to baseline; D/C w/o reintroduction if elev. AST/ALT w/ clinical sx of hepatotoxicity or serum bilirubin >2x ULN, or if AST/ALT >8x ULN

[>40 kg]

Dose: 125 mg PO bid; Start: 62.5 mg PO bid x4wk; Max: 250 mg/day; Info: decr. dose to 62.5 mg bid or interrupt tx and monitor at least q2wk if AST/ALT >3x up to 5x ULN; D/C and monitor at least q2wk if AST/ALT >5x up to 8x ULN; may restart tx if AST/ALT return to baseline; D/C w/o reintroduction if elev. AST/ALT w/ clinical sx of hepatotoxicity or serum bilirubin >2x ULN, or if AST/ALT >8x ULN

Renal dosing

renal impairment: no adjustment

HD/PD: not defined

Hepatic dosing

Child-Pugh Class B or C or baseline AST/ALT >3x ULN: avoid use

SRC: NLM .