Trabectedin Dosage

Generic name: trabectedin
Brand name: Yondelis
Drug class: Alkylating agents

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ

Special Note

[uses, dosing may vary]
Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments

Liposarcoma, metastatic or unresectable

[1.5 mg/m^2/24h IV infusion q3wk]

Leiomyosarcoma, metastatic or unresectable

[1.5 mg/m^2/24h IV infusion q3wk]

Renal dosing

CrCl >30: no adjustment; CrCl <30: not defined
HD/PD: not defined

Hepatic dosing

bilirubin 1.6-3x ULN and AST/ALT <8x ULN: 0.9 mg/m^2/dose q3wk; bilirubin >3x ULN and any AST/ALT: avoid use

 

SRC: NLM .