Trabectedin Dosage
Generic name: trabectedin
Brand name: Yondelis
Drug class: Alkylating agents
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments
Liposarcoma, metastatic or unresectable
- [1.5 mg/m^2/24h IV infusion q3wk]
Leiomyosarcoma, metastatic or unresectable
- [1.5 mg/m^2/24h IV infusion q3wk]
Renal dosing
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
Hepatic dosing
- bilirubin 1.6-3x ULN and AST/ALT <8x ULN: 0.9 mg/m^2/dose q3wk; bilirubin >3x ULN and any AST/ALT: avoid use
SRC: NLM .