Tpoxx Dosage

Generic name: tecovirimat
Dosage form: capsules and injection

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  CAP: 200 mg; INJ: various

Restricted Distribution in US

Special Note, Monkeypox

[FDA expanded access investigational new drug (EA-IND)]

Info: for monkeypox in pts w/ suspected or confirmed infection w/ severe dz or aberrant infection or at high risk for severe dz; for monkeypox post-exposure prophylaxis considered on an individual case-by-case basis in consultation w/ CDC; not FDA approved for monkeypox; avail. from Strategic National Stockpile, contact local health department or CDC (770-488-7100 or poxvirus@cdc.gov)

[mandatory reporting for EA-IND]

Info: serious adverse events must be reported to CDC (regaffairs@cdc.gov) using the FDA MedWatch Form (www.fda.gov/medwatch/report.htm)

Smallpox

[40-119 kg]

Dose: 600 mg PO bid x14 days; Info: give w/in 30min after full moderate-high fat meal

[>120 kg]

Dose: 600 mg PO tid x14 days; Info: give w/in 30min after full moderate-high fat meal

Monkeypox

[PO form, 40-119 kg]

Dose: 600 mg PO bid x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz per FDA EA-IND; may extend duration up to 90 days based on clinical response; give w/in 30min after full moderate-high fat meal

[PO form, >120 kg]

Dose: 600 mg PO tid x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz per FDA EA-IND; may extend duration up to 90 days based on clinical response; give w/in 30min after full moderate-high fat meal

[IV form, 35-119 kg]

Dose: 200 mg IV q12h x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz per FDA EA-IND; switch to PO regimen ASAP to complete course; may extend duration up to 90 days based on clinical response

[IV form, >120 kg]

Dose: 300 mg IV q12h x14 days; Info: for pts w/ severe dz or aberrant infection, or at high risk for severe dz per FDA EA-IND; switch to PO regimen ASAP to complete course; may extend duration up to 90 days based on clinical response

Renal dosing

[PO route]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

[IV route]

CrCl >80: no adjustment; CrCl 30-80: not defined, caution advised; CrCl <30: contraindicated; Info: PO route preferred due to accumulation of toxic IV vehicle

HD/PD: contraindicated

Hepatic dosing

[no adjustment]

SRC: NLM .