Totect Dosage
Generic name: dexrazoxane
Drug class: Miscellaneous uncategorized agents
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
Cardiomyopathy prophylaxis, doxorubicin-assoc.
- [10:1 dexrazoxane:doxorubin ratio IV x1 before each doxorubicin dose]
- Info: for pts w/ metastatic breast CA who have received cumulative doxorubicin dose of 300 mg/m^2 and are continuing doxorubicin tx; give doxorubicin w/in 30min after completing dexrazoxane dose
Extravasation tx, IV anthracycline-assoc.
- [1000 mg/m^2/dose IV q24h x2 on days 1-2, then 500 mg/m^2/dose IV x1 on day 3]
- Start: ASAP w/in 6h of extravasation; Max: 2000 mg/dose on days 1-2, 1000 mg/dose on day 3
Renal dosing
- [adjust dose amount]
- CrCl <40: decr. usual dose by 50%
- HD/PD: not defined
Hepatic dosing
- [cardiomyopathy prophylaxis use]
- hepatic impairment: reduce dose proportionally to reduction in doxorubicin dose, maintaining 10:1 ratio
- [extravasation tx use]
- hepatic impairment: avoid use
SRC: NLM .