Topamax Dosage
Generic name: topiramate
Brand names: Topamax, Topamax Sprinkle
Drug class: Carbonic anhydrase inhibitor anticonvulsants
Medically reviewed by A Ras MD
Recommended Adult Dosing
Dosage forms: SPRINKLE CAP: 15 mg, 25 mg; TAB: 25 mg, 50 mg, 100 mg, 200 mg
Partial seizures
- [monotherapy]
- Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, incr. by 50 mg/day qwk until 100 mg PO bid, then incr. by 100 mg/day qwk; Info: taper dose gradually to D/C
- [adjunct tx]
- Dose: 100-200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective, may incr. ADR risk; taper dose gradually to D/C
Seizures, primary generalized tonic clonic
- [monotherapy]
- Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, incr. by 50 mg/day qwk until 100 mg PO bid, then incr. by 100 mg/day qwk; Info: taper dose gradually to D/C
- [adjunct tx]
- Dose: 200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: taper dose gradually to D/C
Seizures, Lennox-Gastaut syndrome
- [adjunct tx]
- Dose: 100-200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: taper dose gradually to D/C
Migraine headache prophylaxis
- [50 mg PO bid]
- Start: 25 mg PO qhs x1wk, incr. by 25 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C
Sleep-related eating disorder
- [25-100 mg PO qhs]
- Start: 25 mg PO qhs x1wk, then may incr. by 25 mg/day qwk; Info: taper dose gradually to D/C
Nightmares, post-traumatic stress disorder-assoc.
- [75 mg PO qhs]
- Start: 25 mg PO qhs x1wk, then incr. by 25 mg/day qwk; Info: taper dose gradually to D/C
*Alcohol dependence
- [100-150 mg PO bid]
- Start: 25 mg PO qd x1wk, then incr. by 25 mg/day qwk; Info: taper dose gradually to D/C
Renal dosing
- [adjust dose amount]
- CrCl <70: decr. usual dose by 50%
- HD: decr. usual dose, amount not defined, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined
Hepatic dosing
- [not defined]
- hepatic impairment: caution advised
SRC: NLM .