Tolsura Dosage

Brand names: Onmel, Sporanox, Sporanox PulsePak, Tolsura
Drug class: Azole antifungals

Medically reviewed by  A Ras MD

 Recommended Adult Dosing

Dosage forms:  CAP: 65 mg

Special Note

[formulation clarification]

Info: not interchangeable w/ other itraconazole products; do not substitute on a mg to mg basis

Infections, fungal

[130 mg PO qd-bid]

Start: 130 mg PO tid x3 days for life-threatening infections; Info: dose, duration vary by indication; divide dose bid if >130 mg/day; give w/ food; do not open cap

Blastomycosis

[130 mg PO qd]

Info: may incr. by 65 mg if no improvement, max 260 mg/day; divide dose bid if >130 mg/day; give w/ food; do not open cap; start 130 mg PO tid x3 days if life-threatening infection

Histoplasmosis

[130 mg PO qd]

Info: may incr. by 65 mg if no improvement, max 260 mg/day; divide dose bid if >130 mg/day; give w/ food; do not open cap; start 130 mg PO tid x3 days if life-threatening infection

Aspergillosis

[130 mg PO qd-bid]

Info: divide dose bid if >130 mg/day; give w/ food; do not open cap; start 130 mg PO tid x3 days if life-threatening infection

Renal dosing

renal impairment: not defined, caution advised

HD/PD: not defined

Hepatic dosing

hepatic impairment: caution advised

SRC: NLM .