Tibsovo Dosage

Recommended Adult Dosing

Dosage forms: TAB: 250 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

IDH1-mutated AML

[newly diagnosed dz]

Dose: 500 mg PO qd for at least 6mo; Info: for pts 75 yo and older, or who are ineligible for intensive induction chemo d/t comorbidities; use w/ azacitidine or as monotherapy; do not cut/crush/chew tab; avoid admin. w/ high fat meal

[relapsed or refractory dz]

Dose: 500 mg PO qd for at least 6mo; Info: do not cut/crush/chew tab; avoid admin. w/ high fat meal

IDH1-mutated cholangiocarcinoma, locally advanced or metastatic

[500 mg PO qd]

Info: for pts w/ previously treated dz; do not cut/crush/chew tab; avoid admin. w/ high fat meal

Renal dosing

eGFR >30: no adjustment; eGFR <30: not defined

HD/PD: not defined

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

SRC: NLM .

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