Tibsovo Dosage
Generic name: ivosidenib
Drug class: Miscellaneous antineoplastics
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 250 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
IDH1-mutated AML
- [newly diagnosed dz]
- Dose: 500 mg PO qd for at least 6mo; Info: for pts 75 yo and older, or who are ineligible for intensive induction chemo d/t comorbidities; use w/ azacitidine or as monotherapy; do not cut/crush/chew tab; avoid admin. w/ high fat meal
- [relapsed or refractory dz]
- Dose: 500 mg PO qd for at least 6mo; Info: do not cut/crush/chew tab; avoid admin. w/ high fat meal
IDH1-mutated cholangiocarcinoma, locally advanced or metastatic
- [500 mg PO qd]
- Info: for pts w/ previously treated dz; do not cut/crush/chew tab; avoid admin. w/ high fat meal
Renal dosing
- eGFR >30: no adjustment; eGFR <30: not defined
- HD/PD: not defined
Hepatic dosing
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
SRC: NLM .