Thioguanine Dosage
Generic name: thioguanine
Brand name: Tabloid
Drug class: Antimetabolites
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 40 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
AML
- [combo tx, induction tx]
- Dose: 100 mg/m^2/dose PO q12h x8-21 days; Info: decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) deficiency
- [monotherapy, induction and consolidation tx]
- Dose: 2 mg/kg/dose PO qd; Info: may incr. dose to 3 mg/kg/dose PO qd after 4wk; decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) deficiency
ALL, late intensification tx
- [60 mg/m^2/dose PO qd on days 29-42 of 56-day cycle]
- Info: decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) deficiency
Renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
Hepatic dosing
- [not defined]
SRC: NLM .