Thalomid Dosage

Generic name: thalidomide
Drug classes: Leprostatics, Miscellaneous antineoplastics, Other immunosuppressants

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  CAP: 50 mg, 100 mg, 150 mg, 200 mg

Restricted Distribution in US

Special Note

[uses, dosing may vary]
Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

Multiple myeloma, newly diagnosed

[combo w/ dexamethasone]
Dose: 200 mg PO qhs; Info: give >1h after meal
[combo w/ bortezomib, daratumumab, and dexamethasone]
Dose: 100 mg PO qhs; Info: for pts eligible for autologous HSCT; give >1h after meal
[combo w/ bortezomib, daratumumab/hyaluronidase, and dexamethasone]
Dose: 100 mg PO qhs; Info: for pts eligible for autologous HSCT; give >1h after meal

Leprosy reaction, type 2 (erythema nodosum leprosum), cutaneous

[acute tx]
Dose: 100-400 mg PO qhs; Info: for pts w/ mod-severe cutaneous dz; start at lower dose range in pts <50 kg; may start at higher dose range up to 400 mg PO qhs or in divided doses in pts w/ severe dz or w/ hx of high-dose use; may use w/ corticosteroid in pts w/ mod-severe neuritis associated w/ severe dz; continue tx for >2wk until active s/sx improve, then taper dose by 50 mg/day q2-4wk to D/C; give >1h after meal
[maintenance tx]
Dose: 100-400 mg PO qhs; Info: give lowest dose necessary to control dz; for pts who flare during tapering, or w/ hx of requiring prolonged tx to prevent recurrence; attempt tapering dose q3-6mo by 50 mg/day q2-4wk to D/C; give >1h after meal

Cachexia, HIV-assoc.

[100-300 mg PO qhs]
Info: give >1h after meal

Aphthous ulcer, HIV-assoc.

[200 mg PO qhs]
Info: give >1h after meal

Renal dosing

[no adjustment]
renal impairment: no adjustment
HD/PD: no adjustment; no supplement

Hepatic dosing

[not defined]

SRC: NLM .