Temodar Dosage

Generic name: temozolomide (oral/injection)
Drug class: Alkylating agents

Medically reviewed by  A Ras MD

 

 Recommended Adult Dosing

Dosage forms:  CAP: 100 mg, 140 mg, 180 mg, 250 mg; INJ: various

Special Note

[uses, dosing may vary]
Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments

Anaplastic astrocytoma, refractory

[200 mg/m^2/dose PO/IV qd on days 1-5 of 28-day cycle starting cycle 2]
Start: 150 mg/m^2/dose PO/IV qd on days 1-5 of 28-day cycle for cycle 1; Info: do not open/crush/chew cap; give on empty stomach

Glioblastoma multiforme, newly diagnosed

[concomitant focal XRT phase]
Dose: 75 mg/m^2/dose PO/IV qd x42-49 days; Info: PCP prophylaxis required; do not open/crush/chew cap; give on empty stomach
[maintenance phase]
Dose: 200 mg/m^2/dose PO/IV qd on days 1-5 of 28-day cycle starting cycle 2; Start: 150 mg/m^2/dose PO/IV qd on days 1-5 of 28-day cycle for cycle 1, starting 4wk after completing concomitant focal XRT phase; Info: give x6 cycles; do not open/crush/chew cap; give on empty stomach

Malignant melanoma

[monotherapy]
Dose: 150-200 mg/m^2/dose PO qd on days 1-5 of 28-day cycle; Info: do not open/crush/chew cap; give on empty stomach
[combo tx]
Dose: 150 mg/m^2/dose PO qd on days 1-4 of 21-day cycle; Info: do not open/crush/chew cap; give on empty stomach

Renal dosing

[see below]
CrCl >36: no adjustment; CrCl <36: not defined
HD/PD: not defined

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

 

SRC: NLM .