Tegsedi Dosage
Generic name: inotersen
Drug class: Miscellaneous metabolic agents
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ (pre-filled syringe): 284 mg per 1.5 mL
Restricted Distribution in US
Polyneuropathy, hereditary transthyretin-mediated amyloidosis-assoc.
- [284 mg SC qwk]
- Info: vitamin A supplementation recommended; hold if Plt <100,000, urinary protein creatinine ratio >1000 mg/g, or eGFR decr. to <45, see pkg insert
Renal dosing
- [see below]
- eGFR 30-89: no adjustment; eGFR <30: not defined; Info: hold if eGFR decr. to <45 during tx
- HD/PD: not defined
Hepatic dosing
- mild impairment: no adjustment; mod-severe impairment: not defined
SRC: NLM .