Taxotere Dosage

Generic name: docetaxel
Drug class: Mitotic inhibitors

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments

Breast CA

[node-positive adjuvant tx]

Dose: 75 mg/m^2/dose IV x1 on day 1 of 21-day cycle; Info: give x6 cycles; part of multi-drug chemo regimen

[locally advanced or metastatic dz, monotherapy]

Dose: 60-100 mg/m^2/dose IV x1 on day 1 of 21-day cycle

[*metastatic dz, combo w/ capecitabine]

Dose: 75 mg/m^2/dose IV x1 on day 1 of 21-day cycle; Info: for anthracycline-resistant dz

Non-small cell lung CA, locally advanced or metastatic

[75 mg/m^2/dose IV x1 on day 1 of 21-day cycle]

Info: use w/ cisplatin for tx-naive pts or as monotherapy for platinum-resistant dz

Prostate CA

[metastatic castration-resistant dz]

Dose: 75 mg/m^2/dose IV x1 on day 1 of 21-day cycle; Info: give up to 10 cycles; use w/ prednisone 5 mg PO bid

[*metastatic castration-sensitive dz]

Dose: 75 mg/m^2/dose IV x1 on day 1 of 21-day cycle; Info: give x6 cycles; use as monotherapy or in combo w/ darolutamide; give 1st cycle w/in 6wk after starting darolutamide if combo tx

Gastric CA, advanced

[75 mg/m^2/dose IV x1 on day 1 of 21-day cycle]

Info: part of multi-drug chemo regimen

Squamous cell head/neck CA, locally advanced

[75 mg/m^2/dose IV x1 on day 1 of 21-day cycle]

Info: give x3-4 cycles; part of multi-drug chemo regimen

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

bilirubin >ULN: avoid use; AST and/or ALT >1.5x ULN w/ alk phos >2.5x ULN: avoid use

SRC: NLM .