Tarceva Dosage
Generic name: erlotinib
Drug class: EGFR inhibitors
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 25 mg, 100 mg, 150 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
Non-small cell lung CA, metastatic
- [150 mg PO qd]
- Info: for tumors w/ EGFR exon 19 deletions or exon 21 (L858R) substitution mutations; incr. dose by 50 mg/day q2wk up to 300 mg/day if concurrent cigarette smoking, immediately return to usual dose upon smoking cessation; give >1h before or 2h after food
Pancreatic CA, locally advanced or metastatic
- [100 mg PO qd]
- Info: use w/ gemcitabine; incr. dose by 50 mg/day q2wk up to 300 mg/day if concurrent cigarette smoking, immediately return to usual dose upon smoking cessation; give >1h or 2h after food
Renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
Hepatic dosing
- [not defined]
- Child-Pugh Class A, B, or C or bilirubin > ULN: monitor closely; see pkg insert for adjustments based on LFT changes in pts w/ baseline abnormalities
SRC: NLM .