Tarceva Dosage

Generic name: erlotinib
Drug class: EGFR inhibitors

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  TAB: 25 mg, 100 mg, 150 mg

Special Note

[uses, dosing may vary]
Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

Non-small cell lung CA, metastatic

[150 mg PO qd]
Info: for tumors w/ EGFR exon 19 deletions or exon 21 (L858R) substitution mutations; incr. dose by 50 mg/day q2wk up to 300 mg/day if concurrent cigarette smoking, immediately return to usual dose upon smoking cessation; give >1h before or 2h after food

Pancreatic CA, locally advanced or metastatic

[100 mg PO qd]
Info: use w/ gemcitabine; incr. dose by 50 mg/day q2wk up to 300 mg/day if concurrent cigarette smoking, immediately return to usual dose upon smoking cessation; give >1h or 2h after food

Renal dosing

[see below]
renal impairment: no adjustment
HD/PD: not defined

Hepatic dosing

[not defined]
Child-Pugh Class A, B, or C or bilirubin > ULN: monitor closely; see pkg insert for adjustments based on LFT changes in pts w/ baseline abnormalities

SRC: NLM .